Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD

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Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD.

The negative blood oxygenation level-dependent (BOLD) signal following the cessation of stimulation (post-stimulus BOLD undershoot) is observed in functional magnetic resonance imaging (fMRI) studies. However, its spatial characteristics are unknown. To investigate this, gradient-echo BOLD fMRI in response to visual stimulus was obtained in isoflurane-anesthetized cats at 9.4 T. Since the middl...

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Purpose A dual-echo spiral arterial spin labeling (ASL) technique provides simultaneous measurements of cerebral blood flow (CBF) and BOLD responses to brain activation, and has been applied in a calibrated-BOLD methodology to assess the coupling of CBF and the cerebral metabolic rate of O2 (CMRO2) [1-3]. However, the potential of this approach to provide a quantitative probe of the CBF and BOL...

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ژورنال

عنوان ژورنال: NeuroImage

سال: 2007

ISSN: 1053-8119

DOI: 10.1016/j.neuroimage.2006.10.016